Mass‐Spectrometry‐Based Proteomics: General Overview and Posttranslational Modification Analysis in the Context of Platelet Research

In recent years, mass spectrometry-based proteomics has become an indispensable tool allowing the analysis of protein patterns and sensitive changes of post-translational modifications (PTMs). Mass spectrometry has been increasingly applied for platelet research, thereby enabling the analysis of functionally relevant processes on a molecular level, especially with regard to PTM-regulated activation/inhibition. In this chapter a general overview including the analysis of PTM is presented and respective platelet studies are discussed.