Do biological molecular machines act as Maxwell's demons?

The nanoscopic isothermal machines are not only free energy but also information transducers. We show that the generalized fluctuation theorem with information creation and entropy reduction can be fulfilled for the enzymatic molecular machines with the stochastic dynamics which offers a choice of the work performance in variety of ways. A particular model of such dynamics is investigated. The main conclusion of the study is that the free energy processing has to be distinguished from the organization processing. From the former point of view, Maxwell's demon utilizes entropy reduction ultimately for the performance of work, whereas from the latter, which can be the case of biological molecular machines, only for the creation of information. From a broader biological perspective, three suppositions could be of especial importance: (i) a possibility of the choice is characteristic for many intrinsically disordered proteins, (ii) it takes place in the long lasting transient stage before completing the free energy transduction cycle, and (iii) a partial compensation of entropy production by information creation is the reason for most protein machines to operate as dimers or higher organized structures.