Genetic Engineering of T Cells with Receptors from NY-ESO-1-specific Tumor-Recognizing CD4+ T Cell As a Novel Approach for Adoptive T Cell Therapy

Junko Matsuzaki,Takemasa Tsuji,Immanuel Luescher,Hiroshi Shiku,Junichi Mineno,Sachiko Okamoto,Lloyd Old,Protul Shrikant,Sacha Gnjatic, Kunle Odunsi

Journal for immunotherapy of cancer（2015）

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摘要

Meeting abstracts Tumor antigen-specific CD4+ T cells generally orchestrate and regulate innate and adaptive immune cells to provide immune surveillance against malignancy. However, activation of antigen-specific CD4+ T cells is restricted at local tumor sites where antigen-presenting cells are

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关键词

Ovarian Cancer Patient,Intracellular Cytokine Staining,Adaptive Immune Cell,Direct Recognition,Effective Eradication

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