Combining Bace1 Inhibition With Metal Chelation As Possible Therapy For Alzheimer'S Disease
DRUG DESIGN AND DISCOVERY IN ALZHEIMER'S DISEASE（2014）
Key words
A beta aggregation,Alzheimer's disease,amino imidazoles,amyloid beta precursor protein,amyloid plaque,Bi-functional compounds,clinical development,cyclic hydroxyethylamines,dementia,fragment-based lead generation,high-throughput screening,metal chelators,multi-targeted drugs,neurodegenerative disorders,oxidative stress,peptidomimetics,reactive oxygen species,substrate-based design,beta-secretase (BACE1),gamma-secretase
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