Synthesis with Antibacterial and Antifungal Screening of 4- Hydroxy-4- Phenyl Piperidine Derivatives

The present study was aimed to develop Piperidine analogues having high impact medicinal significance. As the outstanding position of piperidine and its derivatives has proven them an important core in the structures of pharmaceutically active molecules and as synthetic intermediates with interesting biological, physical and pharmacological behaviors. Hence a new sequence of 4-Hydoxy -4- Phenyl piperidine derivatives (II-VI) were synthesized with different phenacyl halide. The newly synthesized compounds were structurally proved by various analytical and spectroscopic methodologies. Furthermore these compounds were screened for their in vitro antibacterial and antifungal activities against different pathogens and the structure-activity relationship (SAR) was studied according to the attitude of synthesized compounds towards microbes. The outcome of study reveals the resistance of the parent compounds for organisms but the substitution specifically of pthalamide led to a prominent enhancement of both the activities.