A RARE GIANT EXTRA-GASTROINTESTINAL STROMAL TUMOR (GIST) IN A YOUNG MALE PATIENT

Gastrointestinal stromal tumors (GIST-s) are the most common mesenchimal tumors. They occur usually in older age, through the whole digestive tube, but predominantly in the stomach (60%), and most rarely in oesopagus (<1%). Symptoms and signs of GISTs depend on the size and localization of the tumor. Diagnosis is based on pathohistological analyses that include immuno-histochemical staining. Prognosis of these tumors depend of mitotic index, size of tumor, localization, presence of necrosis, bleeding in tumor, infiltration of mucosa and serosa, presence of lymphogenic and liver metastasis. Regarding these parameters, GISTs are classified as high, intermediate, low or very low risk tumors. Standard therapy for GISTs is surgical treatment, and adjuvant treatment with inhibitors of tyrosine kinase depends on risk stratification. In this paper, the case of 37-year old male with giant GIST of extraintestinal localization is described. Tumors of this localization are extremely rare, and data about this issue in literature are scarce. Acta Medica Medianae 2014;53(4):37-41.