Intramolecular Oxidative Pd(Ii)-Catalyzed Alkoxylation of 3-Aza-5-alkenols with O-2 As Sole Oxidant: Mild Conditions for the Synthesis of 1,4-Oxazine Derivatives

Synthesis of 1,4-2H-oxazine derivatives was performed by Pd(II)-catalyzed aerobic oxidative cyclization of 3-aza-5-alkenols, prepared from easily available 1,2-amino alcohols. The reaction proceeds in very mild conditions with a simple catalytic system consisting of PdCl2(MeCN)(2) in THF at room temperature with molecular oxygen as the sole stoichiometric oxidant.