Discovery of a Novel Tricyclic 4H-Thiazolo[5′,4′:4,5]Pyrano[2,3-c]pyridine-2-amino Scaffold and Its Application in a PI3Kα Inhibitor with High PI3K Isoform Selectivity and Potent Cellular Activity
Bioorganic & Medicinal Chemistry Letters（2015）
关键词
Oncology,Phosphatidylinositol-3-kinase (PI3K),Selective PI3K alpha Inhibitor,4H-Thiazolo[5 ',4 ':4,5]pyrano[2,3-c]pyridine-2-amino derivative
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