Discovery of a novel tricyclic 4H-thiazolo[5′,4′:4,5]pyrano[2,3-c]pyridine-2-amino scaffold and its application in a PI3Kα inhibitor with high PI3K isoform selectivity and potent cellular activity
Bioorganic & Medicinal Chemistry Letters（2015）
Key words
Oncology,Phosphatidylinositol-3-kinase (PI3K),Selective PI3Kα Inhibitor,4H-Thiazolo[5′,4′:4,5]pyrano[2,3-c]pyridine-2-amino derivative
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