Abstract T P139: Prevalence and Predictors of Mood Disorders among a National Sample of Individuals with Stroke or Transient Ischemic Attack

Intro: Depression is an independent stroke risk factor, yet little is known about comorbid mood disorders prevalence in stroke survivors. Data regarding association between mood disorders and transient ischemic attack (TIA) are scarce. Objective: To determine prevalence and predictors of comorbid mood disorders among individuals hospitalized with TIA, ischemic stroke, and hemorrhagic stroke in a national US sample. Methods: Using Nationwide Inpatient Sample (NIS) data (2000-2010), we identified individuals discharged with a primary diagnosis of acute ischemic stroke, hemorrhagic stroke, or TIA. We determined the weighted proportion of stroke hospitalizations with comorbid mood disorders (bipolar affective disorder, depression, anxiety disorders). We used survey weighted Poisson regression to estimate risk ratios. The first multivariable model adjusted for sociodemographic and hospital factors. The second model also adjusted for comorbid conditions. Results: Among 2,057,799 hospital discharges for stroke or TIA (corresponding to 10.1 million individuals in US), 83,705 (4.07%) had mood disorders. Compared to those without mood disorders, individuals with mood disorders were younger and more likely to be female, White, and had higher income and private insurance. Individuals 84 years (RR 3.61, 95% CI 3.50-3.72) after adjustment for sociodemographic and hospital factors. Further adjustment for comorbidities slightly attenuated the association (RR 3.30, 95% CL 3.19-3.40). Women were twice as likely to have mood disorders (RR 1.94, 95% CI 1.91-1.97), after adjusting for sociodemographic and hospital factors. Further adjustment for comorbidities did not affect the association. Compared to Whites, all other races were less likely to have mood disorders. Conclusions: In this national sample of individuals admitted with stroke or TIA, 4% had mood disorders. This is likely an underestimate, given lack of systematic screening for comorbid psychiatric disease. Women, younger individuals, and Whites appear to be a population at risk; however, further studies are needed to determine the true prevalence of mood disorders among individuals with TIA/stroke, to determine impact on stroke recovery and optimal treatment options.