Synthesis and biological evaluation of strained unusual amino acid containing tetrapeptides as potential antidepressant agents

Prathama S Mainkar,Sumana Chakravarty, Takkallapally Srujana,Libi Anandi Vishwanathan,Santosh Kumar Prajapti,Karisetty Bhanu Chandra,Lenin Veeraval,Bathini Nagendra Babu

Bioorganic Chemistry（2015）

引用 6|浏览1

暂无评分

摘要

•Design and synthesis of GLYX-13 analogs using novel strained unusual β-amino acids.•Compounds were studied for neurite growth, antidepressant properties.•Forced swim test was performed for behavioural assay and compared with GLYX-13.•Compounds 11a, 11b were studied for gene expression and neuroprotective property.•Molecular docking study of synthesized compound in active site of NMDA receptors.

查看译文

关键词

NMDA receptor,GRIN2B,Norbornane amino acid,Neurotrophic

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要