Design and Optimization of Curcumin–HPβCD Bioadhesive Vaginal Tablets by 23 Factorial Design: In Vitro and In Vivo Evaluation

Umme Hani,H G Shivakumar,Atul Srivastava,Nawaz Mahammed,Shailesh Thirumaleshwar,Naga Sravan Kumar Varma,Rudra Vaghela,Chetan G Shinde,M P Gowrav

Journal of Pharmaceutical Innovation（2015）

Cited 8|Views2

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Abstract

Candida albicans is the major cause of candidiasis. Better patient compliance and therapeutic efficacy can be achieved by utilizing herbal antifungal agent curcumin which is 2.5-fold more potent than fluconazole at inhibiting the adhesion of C. albicans.

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Key words

Curcumin–HPβCD bioadhesive vaginal tablet, Vaginal candidiasis, 23 factorial design, 3D response curve, X-ray image

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