PP199—Intracellular Concentration of Darunavir as an Indicator for the Clinical Efficacy in HIV Patients

Darunavir (DRV), a protease inhibitor, potently suppresses the replication of wild-type and drug-resistant HIV-1, but its clinical efficacy varies greatly among individuals. Recently, the importance of the concentrations of DRV in blood cells, the site of action for DRV, has been focused. In this study, we assessed the influence of plasma and intracellular concentration of DRV on its clinical efficacy. The factors acting for the intracellular concentration of DRV is also investigated.