Sinomenine Derivatives with Embedment of Nitrogen-Containing Heterocycles Exhibiting Potent TNF-αinhibitory Activity

Meng Wang,LiYan Ma,YangTong Lou,Chao Bian,TingTing Zhou,HaiBin Zhou,HongZe Liao,Zhao Ma,DongSheng Yin,AiZhong Chen,ShaoZhong Wang,ZhenYu Yang,Bing Sun,ZhuJun Yao

Science China Chemistry（2012）

引用 9|浏览14

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摘要

Inhibitory effect on tumor necrosis factor-α (TNF-α) production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work. Several new sinomenine derivatives having chlorophenyl substituent have been found to exhibit much more potent TNF-α inhibitory activity than natural sinomenine and other derivatives.

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关键词

sinomenine,druggability,heterocycle,tumor necrosis factor-α,inhibition

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