Gene Expression Relationship Between Prostate Cancer Cells of Gleason 3, 4 and Normal Epithelial Cells As Revealed by Cell Type-Specific Transcriptomes

Laura E Pascal,Ricardo ZN Vêncio,Laura S Page,Emily S Liebeskind,Christina P Shadle,Pamela Troisch,Bruz Marzolf,Lawrence D True,Leroy E Hood,Alvin Y Liu

BMC Cancer（2009）

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摘要

Prostate cancer cells in primary tumors have been typed CD10-/CD13-/CD24hi/CD26+/CD38lo/CD44-/CD104-. This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of tumors is a descriptive of tumor glandular differentiation. Higher Gleason scores are associated with treatment failure.

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关键词

Prostate Cancer,Prostate Cancer Cell,Prostate Cancer Cell Line,Luminal Cell,Prostatic Intraepithelial Neoplasia

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