8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Vassilios Bavetsias,Rachel M. Lanigan,Gian Filippo Ruda,Butrus Atrash,Mark G. McLaughlin,Anthony Tumber,N. Yi Mok,Yann-Vai Le Bihan,Sally Dempster,Katherine J. Boxall,Fiona Jeganathan,Stephanie B. Hatch,Pavel Savitsky,Srikannathasan Velupillai,Tobias Krojer,Katherine S. England,Jimmy Sejberg,Ching Thai,Adam Donovan,Akos Pal,Giuseppe Scozzafava,James M. Bennett,Akane Kawamura,Catrine Johansson,Aleksandra Szykowska,Carina Gileadi,Nicola A. Burgess-Brown,Frank von Delft,Udo Oppermann,Zoe Walters,Janet Shipley,Florence I. Raynaud,Susan M. Westaway, Rab K. Prinjha,Oleg Fedorov,Rosemary Burke,Christopher J. Schofield,Isaac M. Westwood,Chas Bountra,Susanne Mueller,Rob L. M. van Montfort,Paul E. Brennan,Julian Blagg Journal of medicinal chemistry（2016）
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