Evolution: Redefining gene essentiality
NATURE REVIEWS GENETICS(2016)
摘要
Our current definition of essential genes is based on whether or not gene knockout cells survive. Rancati and colleagues now reveal a new class of essential genes — called 'evolvable essential genes' — that can overcome loss of function with time by evolving alternative, usually unrelated, cellular processes driven by aneuploidy. To identify evolvable essential genes… Download references
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关键词
Molecular evolution
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