The Value of Narrow-Band Imaging with Magnifying Endoscopy in Diagnosis of Early Gastric Cancer：a Meta-Analysis

Objective: To assess the diagnostic value of narrow-band imaging with magnifying endoscopy ( NBI-ME ) for early gastric cancer ( EGC ) .Methods: We searched PubMed, Embase, Web of Science and the Cochrane Library for literature of NBI-ME in diagnosis of EGC, and then performed meta-analysis.Results:A total of 12 articles involving 2 278 samples from 2 048 patients were included. The overall sensitivity of NBI-ME for diagnosis of EGC was 0.84 [95% CI: 0.80 ~0.87], specificity was 0.96 (95%CI:0.95~0.97),and area under the symmetric receiver operator characteristic curve (AUC) was 0.9592.The AUC value of the NBI-ME plus conventional white light endoscopy ( C-WLE) subgroup (0.9706) was higher than that of NBI-ME alone ( 0.8162 ) .The incremental yield of NBI-ME plus C-WLE over C-WLE was significant ( IY=9 .4%, P=0 .011 ) , while NBI-ME alone over C-WLE was not significant (IY=0.8%, P =0.498).Conclusions: The results show that NBI-ME plus C-WLE is an effective and preferable method for diagnosis of EGC;however, NBI-ME alone is not superior to C-WLE.