Dynamic Regulation of Delta-Opioid Receptor in Rat Trigeminal Ganglion Neurons by Lipopolysaccharide-induced Acute Pulpitis.

•LPS-induced dental pulp inflammation represents the process of acute pulpitis.•Acute pulpitis increases DOR protein and gene expression in trigeminal ganglion.•Acute pulpitis gradually increases DOR dimerization in trigeminal ganglion.•Acute pulpitis induces the dynamic change of DOR protein in trigeminal nerve and dental pulp.•Acute pulpitis may cause the inhibition of ERK1/2 and Akt signaling in trigeminal ganglion.