Genomics and drug profiling of fatal TCF3-HLF− positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

Ute Fischer,Michael Forster,Anna Rinaldi,Thomas Risch,Stéphanie Sungalee,Hans-Jörg Warnatz,Beat Bornhauser,Michael Gombert,Christina Kratsch,Adrian M Stütz,Marc Sultan,Joelle Tchinda,Catherine L Worth,Vyacheslav Amstislavskiy,Nandini Badarinarayan,André Baruchel,Thies Bartram,Giuseppe Basso, Cengiz Canpolat,Gunnar Cario,Hélène Cavé, Dardane Dakaj,Mauro Delorenzi,Maria Pamela Dobay,Cornelia Eckert,Eva Ellinghaus,Sabrina Eugster,Viktoras Frismantas,Sebastian Ginzel,Oskar A Haas,Olaf Heidenreich,Georg Hemmrich-Stanisak,Kebria Hezaveh,Jessica I Höll,Sabine Hornhardt,Peter Husemann,Priyadarshini Kachroo,Christian P Kratz,Geertruy te Kronnie,Blerim Marovca,Felix Niggli,Alice C McHardy,Anthony V Moorman,Renate Panzer-Grümayer,Britt S Petersen,Benjamin Raeder,Meryem Ralser,Philip Rosenstiel,Daniel Schäfer,Martin Schrappe,Stefan Schreiber,Moritz Schütte,Björn Stade,Ralf Thiele,Nicolas von der Weid,Ajay Vora,Marketa Zaliova,Langhui Zhang,Thomas Zichner,Martin Zimmermann,Hans Lehrach,Arndt Borkhardt,Jean-Pierre Bourquin,Andre Franke,Jan O Korbel,Martin Stanulla,Marie-Laure Yaspo

Nature genetics（2015）

引用 178|浏览70

暂无评分

摘要

Jean-Pierre Bourquin, Martin Stanulla and colleagues report whole genome, whole exome and transcriptome sequencing of TCF3-HLF fusion–positive acute lymphoblastic leukemia. Drug response profiling in patient-derived xenografts identified sensitivity to the BCL2-specific inhibitor ABT-199 (venetoclax) as a new option for treating this fatal disease.

查看译文

关键词

Acute lymphocytic leukaemia, Personalized medicine

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要