TLR3 Polymorphisms Are Associated with Virologic Response to Hepatitis C Virus (HCV) Treatment in HIV/HCV Coinfected Patients.

María Angeles Jiménez-Sousa,Norma Rallón,Juan Berenguer,Daniel Pineda-Tenor, Juan Carlos López,Vicente Soriano,María Guzmán-Fulgencio,Jaime Cosín,Diana Retana,Mónica García-Álvarez,Pilar Miralles,Jose Miguel Benito,Salvador Resino

Journal of Clinical Virology（2015）

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摘要

•A allele at rs3775291 was associated with decreased odds of response to therapy.•Carriers of rs13126816 A allele infected with GT2/3 had lower proportion of EVR.•The GG haplotype (composed of rs3775291 and rs13126816) was associated with SVR.•TLR3 polymorphisms were associated with response independently of IL28B SNPs.

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关键词

Polymorphisms,HIV,Chronic hepatitis C,Interferon,HCV therapy

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