Antiviral Therapy and Long-Term Outcome for Hepatitis B Virus-Related Hepatocellular Carcinoma after Curative Liver Resection in a Japanese Cohort.

Keita Sakamoto,Toru Beppu,Hiromitsu Hayashi,Shigeki Nakagawa,Hirohisa Okabe,Hidetoshi Nitta,Katsunori Imai,Daisuke Hashimoto,Akira Chikamoto,Takatoshi Isiko,Ken Kikuchi,Hideo Baba

Anticancer research（2015）SCI 4区

Kumamoto Univ

Cited 36|Views9

Abstract

AIM:The aim of this study was to determine whether antiviral therapy with nucleotide/nucleoside analog (NA) is beneficial for Japanese patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) who underwent initial curative liver resection.PATIENTS AND METHODS:In 162 patients with positive hepatitis B surface antigen and negative anti-hepatitis C virus antibody, sixty-two patients received antiviral therapy with NA (NA group) and the remaining 100 patients did not (non-NA group). Prognostic factors for disease-free survival (DFS) and overall survival (OS) were evaluated. Moreover, to equalize the background covariates, a one-to-one propensity case-matched analysis was used.RESULTS:NA administered were lamivudine (LAM) solely for 21 patients, LAM plus adefovir dipivoxil (ADV) for 6, LAM switched to entecavir (ETV) for 5 and ETV solely for 31. DFS did not significantly differ between the NA group and non-NA group (p=0.19). However, OS was significantly different (p=0.0063); 1-,3- and 5-year OS were 100% and 85.9%, 88.3% and 61.9% and 65.1% and 58.0%, respectively. In multivariate analysis, no antiviral therapy with NA was an independent poor prognostic factor (hazard ratio (HR)=2.72; p=0.0229). However, after propensity case-matched analysis, disease-free and overall survival were not significantly different between the two groups.CONCLUSION:In a Japanese cohort, antiviral therapy with NAs might provide longer survival for postoperative HBV-related HCC patients compared to patients without antiviral therapy. However, deterministic evaluation was impossible by this study alone.

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Hepatitis B virus,hepatocellular carcinoma,antiviral therapy,nucleotide/nucleoside analog,propensity score-matching

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