Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations.
FEBS Open Bio（2014）
Key words
APP,Aβ,AICD,AD,FAD,TMD,PS,NTF,CTF,ER,Lep,BD8,GVP,GCB,WT,FLIM/FRET,CHAPSO,Bis-Tris,MSD,RM,CRM,Endo H,MGD
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