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Structure-Based Approach for the Discovery of Pyrrolo[3,2-d]pyrimidine-Based EGFR T790M/L858R Mutant Inhibitors.

Satoshi Sogabe,Youichi Kawakita,Shigeru Igaki,Hidehisa Iwata,Hiroshi Miki,Douglas R Cary,Terufumi Takagi,Shinji Takagi,Yoshikazu Ohta,Tomoyasu Ishikawa

ACS medicinal chemistry letters（2013）

Cited 110|Views20
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Key words
egfr t790/l858 mutant inhibitors,nsclc,tak-285,crystal structure,drug sensitivity and resistance,pyrrolo[3,2-d]pyrimidine derivatives
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