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Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye.

Min Zhong,Thomas R Gadek,Minna Bui,Wang Shen,John Burnier,Kenneth J Barr,Emily J Hanan,Johan D Oslob,Chul H Yu,Jiang Zhu,Michelle R Arkin,Marc J Evanchik,W Mike Flanagan,Ute Hoch,Jennifer Hyde,Saileta Prabhu,Jeffrey A Silverman,Jasmin Wright

ACS medicinal chemistry letters（2012）

引用 79|浏览18
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关键词
LFA-1/ICAM-1 antagonist,SAR 1118,dry eye,ophthalmic solution,tetrahydroisoquinoline derivative
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