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Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.

Seungil Han,Robert M Czerwinski,Nicole L Caspers,David C Limburg,WeiDong Ding,Hong Wang,Jeffrey F Ohren,Francis Rajamohan,Thomas J McLellan,Ray Unwalla,Chulho Choi,Mihir D Parikh,Nilufer Seth,Jason Edmonds,Chris Phillips,Subarna Shakya,Xin Li,Vikki Spaulding,Samantha Hughes,Andrew Cook,Colin Robinson,John P Mathias,Iva Navratilova,Quintus G Medley, David R Anderson,Ravi G Kurumbail,Ann Aulabaugh

BIOCHEMICAL JOURNAL（2014）

Cited 21|Views26
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Key words
allosteric,drug discovery,inhibition mechanism,interleukin-2-inducible T-cell kinase (ITK),kinase inhibitor,structure-based drug design
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