Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1h-pyrazolo-[3,4-b]pyrazine (PF470): a Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mglur5) Negative Allosteric Modulator.
Lei Zhang,Gayatri Balan,Gabriela Barreiro,Brian P. Boscoe,Lois K. Chenard,Julie Cianfrogna,Michelle M. Claffey,Laigao Chen,Karen J. Coffman,Susan E. Drozda,Joshua R. Dunetz,Kari R. Fonseca,Paul Galatsis,Sarah Grimwood,John T. Lazzaro,Jessica Y. Mancuso,Emily L. Miller,Matthew R. Reese,Bruce N. Rogers,Isao Sakurada,Marc Skaddan,Deborah L. Smith,Antonia F. Stepan,Patrick Trapa,Jamison B. Tuttle,Patrick R. Verhoest,Daniel P. Walker,Ann S. Wright,Margaret M. Zaleska,Kenneth Zasadny,Christopher L. Shaffer Journal of Medicinal Chemistry（2014）
AI 理解论文
溯源树
样例
