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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

Kathrin Schmeisser,Johannes Mansfeld,Doreen Kuhlow,Sandra Weimer,Steffen Priebe,Ines Heiland,Marc Birringer,Marco Groth,Alexandra Segref,Yariv Kanfi,Nathan L Price,Sebastian Schmeisser,Stefan Schuster,Andreas F H Pfeiffer,Reinhard Guthke,Matthias Platzer,Thorsten Hoppe,Haim Y Cohen,Kim Zarse,David A Sinclair,Michael Ristow

Nature chemical biology（2013）

Cited 191|Views21
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Abstract
Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, causing upregulation of defense mechanisms that promote longevity.
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nature chemical biology, science
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