Optimization of the indolyl quinolinone class of KDR (VEGFR-2) kinase inhibitors: effects of 5-amido- and 5-sulphonamido-indolyl groups on pharmacokinetics and hERG binding.

Mark E Fraley,Kenneth L Arrington,Carolyn A Buser, Patrice A Ciecko,Kathleen E Coll,Christine Fernandes,George D Hartman,William F Hoffman,Joseph J Lynch,Rosemary C McFall,Keith Rickert,Romi Singh,Sheri Smith,Kenneth A Thomas,Bradley K Wong

Bioorganic & medicinal chemistry letters（2004）

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