Evaluation of the Influence of thiosemicarbazone-triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents.
Bioorganic & Medicinal Chemistry Letters(2013)
摘要
A series of thiosemicarbazone–triazole hybrids 1a–h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired.
更多查看译文
关键词
Thiosemicarbazon–triazole hybrid,Obesity,Diabetics,Lipid
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要