Stochastic machines as a colocalization mechanism for scaffold protein function.

•We constructed a model for the Axin–β-catenin–GSK3β–CKIα complex.•The structured proteins bind to Axin’s longest disordered region.•The resulting structure has structured domains colocalized via flexible linkers.•β-Catenin phosphorylation by the kinases is proposed to occur by random movements.•Unlike typical machines, the stochastic machine parts move without coordination.