Discovery of Potent Selective Bioavailable Phosphodiesterase 2 (PDE2) Inhibitors Active in an Osteoarthritis Pain Model. Part II: Optimization Studies and Demonstration of in Vivo Efficacy.
Bioorganic & Medicinal Chemistry Letters（2013）
关键词
Phosphodiesterase 2 (PDE2) inhibitors,Structure based drug design,Osteoarthritis (OA) pain
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