Chrome Extension
WeChat Mini Program
Use on ChatGLM
VIPCreated with Sketch.

    • Chikungunya Virus Takes Centre Stage in Virally Induced Arthritis: Possible Cellular and Molecular Mechanisms to Pathogenesis

    Marie Christine Jaffar-Bandjee,Trina Das,Jean Jacques Hoarau,Pascale Krejbich Trotot,Melanie Denizot,Anne Ribera,Pierre Roques,Philippe Gasque

    Microbes and Infection（2009）SCI 3区SCI 4区

    Univ Reunion | CEA

    Cited 72|Views20
    Abstract
    Chikungunya virus (CHIKV) causes an acute symptomatic illness with fever, skin rash (hypersensitivity vascultis), incapacitating arthralgia which can evolve to chronic arthritis in elderly patients. Clinical observations from cohort studies have been corroborated with data from experimental infection in several mouse and non-human primate models as discussed herein.
    More
    Translated text
    Key words
    Virus,Arthritis,Immunology
    PDF
    View via Publisher
    Bibtex
    AI Read Science
    AI Summary
    AI Summary is the key point extracted automatically understanding the full text of the paper, including the background, methods, results, conclusions, icons and other key content, so that you can get the outline of the paper at a glance.
    Example
    Background
    Key content
    Introduction
    Methods
    Results
    Related work
    Fund
    Key content
    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
    • We show that M6 outperforms the baselines in multimodal downstream tasks, and the large M6 with 10 parameters can reach a better performance
    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
    • The model is scaled to large model with 10 billion parameters with sophisticated deployment, and the 10 -parameter M6-large is the largest pretrained model in Chinese
    • Experimental results show that our proposed M6 outperforms the baseline in a number of downstream tasks concerning both single modality and multiple modalities We will continue the pretraining of extremely large models by increasing data to explore the limit of its performance
    Try using models to generate summary,it takes about 60s
    Must-Reading Tree
    Example
    Generate MRT to find the research sequence of this paper
    Related Papers

    Chikungunya Virus Infections.

    Fabrice Simon,Emilie Javelle,Manuela Oliver,Isabelle Leparc-Goffart,Catherine Marimoutou
    Current Infectious Disease Reports 2011

    被引用181

    HLA Class I Restriction As a Possible Driving Force for Chikungunya Evolution

    Joo Chuan Tong,Diane Simarmata,Raymond T. P. Lin,Laurent Renia,Lisa F. P. Ng
    PLoS ONE 2010

    被引用16

    Infection À Virus Chikungunya À La Réunion En 2005–2006 : Formes Graves Émergentes De L’adulte En Réanimation

    B. -A. Gaüzère,M. Bohrer,D. Drouet,P. Gasque,M. -C. Jaffar-Bandjee,L. Filleul,D. Vandroux
    REANIMATION 2011

    被引用5

    Perceived Morbidity and Community Burden after a Chikungunya Outbreak: the TELECHIK Survey, a Population-Based Cohort Study

    Patrick Gérardin,Adrian Fianu,Denis Malvy,Corinne Mussard,Karim Boussaïd,Olivier Rollot,Alain Michault,Bernard-Alex Gaüzere,Gérard Bréart,François Favier
    BMC Medicine 2011

    被引用175

    A Mouse Model of Chikungunya Virus-Induced Musculoskeletal Inflammatory Disease Evidence of Arthritis, Tenosynovitis, Myositis, and Persistence

    Thomas E. Morrison,Lauren Oko,Stephanie A. Montgomery,Alan C. Whitmore,Alina R. Lotstein,Bronwyn M. Gunn,Susan A. Elmore,Mark T. Heise
    ˜The œAmerican journal of pathology 2011

    被引用216

    Manifestations Cutanées De La Panleucopénie Féline Chez Un Chat

    X. Langon
    Pratique Médicale et Chirurgicale de l Animal de Compagnie 2010

    被引用0

    Cellular IMPDH Enzyme Activity is a Potential Target for the Inhibition of Chikungunya Virus Replication and Virus Induced Apoptosis in Cultured Mammalian Cells.

    M. Khan,R. Dhanwani,I. K. Patro,P. V. L. Rao,M. M. Parida
    Antiviral Research 2010

    被引用94

    Chikungunya Virus, Epidemiology, Clinics and Phylogenesis: A Review

    Alessandra Lo Presti,Alessia Lai,Eleonora Cella,Gianguglielmo Zehender,Massimo Ciccozzi
    Asian Pacific Journal of Tropical Medicine 2014

    被引用78

    Infection with Mayaro virus in a French traveller returning from the Amazon region, Brazil, January, 2010

    Receveur M C,Grandadam M,Pistone T,Malvy D
    EUROSURVEILLANCE 2010

    被引用66

    Emergence and Clinical Insights into the Pathology of Chikungunya Virus Infection

    Marie Christine Jaffar-Bandjee,Duksha Ramful,Bernard Alex Gauzere,Jean Jacques Hoarau,Pascale Krejbich-Trotot,Stephanie Robin,Anne Ribera,Jimmy Selambarom,Philippe Gasque
    Expert review of anti-infective therapy 2010

    被引用61

    Chikungunya Virus Mobilizes the Apoptotic Machinery to Invade Host Cell Defenses.

    Pascale Krejbich-Trotot,Melanie Denizot,Jean-Jacques Hoarau,Marie-Christine Jaffar-Bandjee,Trina Das,Philippe Gasque
    The FASEB Journal 2010

    被引用120

    Bradykinin Enhances Sindbis Virus Infection in Human Brain Microvascular Endothelial Cells.

    Naiara Miranda Rust,Michelle Premazzi Papa,Aline Miranda Scovino,Mayara Marques Carneiro da Silva,Carlos Eduardo Calzavara-Silva,Ernesto Torres de Azevedo Marques,Ligia Maria Torres Pecanha,Julio Scharfstein,Luciana B. Arruda
    Virology 2011

    被引用17

    Mouse Models for Chikungunya Virus: Deciphering Immune Mechanisms Responsible for Disease and Pathology

    Teck-Hui Teo,Fok-Moon Lum,Wendy W. L. Lee,Lisa F. P. Ng
    Immunologic research 2012

    被引用36

    Polyarthritis in Four Patients with Chikungunya Arthritis.

    Nai Lee Lui,Hoe Nam Leong,Julian Thumboo
    Singapore medical journal 2012

    被引用26

    Central Nervous System Infections in Travelers

    H. L. Kirsch,K. T. Thakur, G. L. Birbeck
    Current Infectious Disease Reports 2013

    被引用1

    Combined Mirna and Mrna Signature Identifies Key Molecular Players and Pathways Involved in Chikungunya Virus Infection in Human Cells.

    Tanvi Saxena,Bhavna Tandon,Shivani Sharma,Shibu Chameettachal,Pratima Ray,Alok R. Ray,Ritu Kulshreshtha
    PLoS ONE 2013

    被引用39

    Experimental Infection of Mice and Baby Chickens with Thailand Strain of Chikungunya Virus

    Sonthaya Tiawshisup, Pichanan Rattanakampol, Warritar Navavichit, Hemmarat Ratpiyapaporn
    The Thai Journal of Veterinary Medicine 2012

    被引用24

    Chikungunya fever: A review of a re-emerging mosquito-borne infectious disease and the current status

    Poying Chia,Mary Mahlee Ng,Justin Jang,Hann Chu, Yong Loo
    2010

    被引用25

    Infection à virus Chikungunya à La Réunion en 2005–2006 : formes graves émergentes de l’adulte en réanimation@@@Chikungunya virus infection in Reunion Island in 2005–2006: severe emerging adult forms in the intensive care unit

    B A Gauzere,M Bohrer,D Drouet, Philippe Gasque,M C Jaffarbandjee,L Filleul,D Vandroux
    2011

    被引用23

    The Global Effort To Tackle The Increasing Incidence Of Chikungunya Infection

    Lara J Herrero,Suresh Mahalingam
    MICROBIOLOGY AUSTRALIA 2011

    被引用22

    Virus-Induced Encephalitis and Innate Immune Responses – A Focus on Emerging or Re-Emerging Viruses

    Melanie Denizot,Vincent G. Thon-Hon,Shiril Kumar,Jim W. Neal,Philippe Gasque
    NON-FLAVIVIRUS ENCEPHALITIS 2011

    被引用1

    Arthrogenic Alphaviruses and Inflammatory Myopathies

    Lara Herrero,Suresh Mahalingam
    Idiopathic Inflammatory Myopathies - Recent Developments 2011

    被引用2

    Chapter 49 - Post-Infectious Arthritis and Reactive Arthritis

    Alvaro Ferreira,Marta Chagas Monteiro,Pedro Vita,Antonio Marinho,Carlos Vasconcelos
    2015

    被引用4

    Bioterrorismus, Infektiologische Aspekte

    Ernst-Jürgen Finke,Herbert Tomaso,Dimitrios Frangoulidis
    Lexikon der Infektionskrankheiten des Menschen 2012

    被引用2

    Fingolimod Treatment Abrogates Chikungunya Virus–induced Arthralgia

    Teck-Hui Teo,Yi-Hao Chan,Wendy W. L. Lee, Fok-Moon Lum,Siti Naqiah Amrun,Zhisheng Her,Ravisankar Rajarethinam,Andres Merits,Olaf Rotzschke,Laurent Renia,Lisa F. P. Ng
    Science Translational Medicine 2017

    被引用52

    A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty’s Syndrome

    José Kennedy Amaral,Robert T. Schoen
    Rheumatology and Therapy 2018

    被引用2

    Paradoxical Effect of Chloroquine Treatment in Enhancing Chikungunya Virus Infection

    Pierre Roques,Simon-Djamel Thiberville,Laurence Dupuis-Maguiraga,Fok-Moon Lum,Karine Labadie,Frederic Martinon,Gabriel Gras,Pierre Lebon,Lisa F. P. Ng,Xavier de Lamballerie,Roger Le Grand
    Viruses 2018

    被引用165

    Sindbis Virus Infection Causes Cell Death by Nsp2-Induced Transcriptional Shutoff or by Nsp3-Dependent Translational Shutoff

    Ivan Akhrymuk,Ilya Frolov,Elena Frolova
    Journal of Virology 2018

    被引用44

    Sindbis virus as a human pathogen-epidemiology, clinical picture and pathogenesis.

    Samuel Adouchief,Teemu Smura,Jussi Sane,Olli Vapalahti,Satu Kurkela
    REVIEWS IN MEDICAL VIROLOGY 2016

    被引用116

    Novel Lesions Of Bones And Joints Associated With Chikungunya Virus Infection In Two Mouse Models Of Disease: New Insights Into Disease Pathogenesis

    Brad A. Goupil,Margaret A. McNulty,Matthew J. Martin,Michael K. McCracken,Rebecca C. Christofferson,Christopher N. Mores
    PLOS ONE 2016

    被引用29

    Data Disclaimer
    The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn
    Chat Paper
    【要点】：本文探讨了基孔肯雅病毒（CHIKV）引起病毒性关节炎的可能细胞和分子机制，以及其在老年患者中可能演变为慢性关节炎的病理过程。
    

    【方法】：通过回顾临床观察和实验感染数据，包括小鼠和非人灵长类模型的研究，分析了CHIKV感染后关节炎的细胞和分子机制。
    

    【实验】：未具体说明实验方法和数据集名称，但提到使用了几种实验感染模型和临床观察数据。
    去 AI 文献库 对话