Enhanced Replication of R5 HIV‐1 Isolates in Vitro by a Small‐Molecule Reagent Targeting HIV‐1 Protease

Nick J. Wardle,Harry R. Hudson,Ray W. Matthews,Christine M. Nunn, Cherelyn Vella,S. W. Annie Bligh

ChemMedChem（2013）

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摘要

CHEMICAL ENHANCEMENT: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.

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关键词

antiviral agents,CCR5,chemokines,HIV-1,R5 isolates,viral replication,vaccine and drug development

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