Pathological subtrochanteric fractures in 194 patients: a comparison of outcome after surgical treatment of pathological and non-pathological fractures.

Background The surgical treatment of pathological subtrochanteric fractures has been associated with technical difficulties and frequent failures. We analyzed survival, risk factors for death, and outcome after surgical treatment. Methods The study group consisted of 194 patients with pathological subtrochanteric femur fractures operated during 19992009. Cox multiple-regression analysis was performed to study risk factors and results were expressed as hazard ratios (HR). We included a control group with non-pathological subtrochanteric fractures (n=87) for comparison. Results The median age at surgery was 68 (2996) years in the study group and 82 (66101) in the controls. The 1-year survival rate after surgery was 33% (95% CI: 2640) in the study group and 85% (7993) in the controls. In the study group, the risk of death after surgery was increased for patients 65 years of age (HR 1.5, 95% CI: 1.12.1), with a moderate (HR 2.2, 1.53.4) and poor (HR 2.9, 1.65.2) Karnofsky score, with visceral metastases (HR 1.6, 1.12.3), and perioperative hemoglobin levels <100g/L (HR 2.2, 1.33.7). In patients with pathological fractures, there was no statistically significant difference concerning reoperation rates comparing intramedullary nails (9%) with endoprostheses (6%; P=0.3). Conclusions Surgery for pathological subtrochanteric femur fractures is a relatively safe and effective procedure. J. Surg. Oncol. 2013;107:498504. (c) 2012 Wiley Periodicals, Inc.