Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors.
Anthony A. Estrada,Bryan K. Chan,Charles Baker-Glenn,Alan Beresford,Daniel J. Burdick,Mark Chambers,Huifen Chen,Sara L. Dominguez,Jennafer Dotson,Jason Drummond,Michael Flagella,Reina Fuji,Andrew Gill,Jason Halladay,Seth F. Harris,Timothy P. Heffron,Tracy Kleinheinz,Donna W. Lee,Claire E. Le Pichon,Xingrong Liu,Joseph P. Lyssikatos,Andrew D. Medhurst,John G. Moffat,Kevin Nash,Kimberly Scearce-Levie,Zejuan Sheng,Daniel G. Shore,Susan Wong,Shuo Zhang,Xiaolin Zhang,Haitao Zhu,Zachary K. Sweeney Journal of medicinal chemistry（2014）
Key words
Multi-Target-Directed Ligands
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