CD3ζ Expression and T Cell Proliferation Are Inhibited by TGF-β1 and IL-10 in Cervical Cancer Patients

Cinthya E. Díaz-Benítez,Karla R. Navarro-Fuentes,Jacqueline A. Flores-Sosa,Janet Juárez-Díaz,Felipe J. Uribe-Salas,Edgar Román-Basaure, Ludwig E. González-Mena,Patricia Alonso de Ruíz,Guillermina López-Estrada,Alfredo Lagunas-Martínez,Victor H. Bermúdez-Morales,Juan M. Alcocer-González,Jesús Martínez-Barnetche,Rogelio Hernández-Pando,Yvonne Rosenstein,José Moreno,Vicente Madrid-Marina

Journal of clinical immunology（2009）

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摘要

Cervical cancer development from a squamous intraepithelial lesion is thought to be favored by an impaired T cell immunity. We evaluated parameters of T cell alterations such as proliferation, cytokine, and CD3ζ expression in peripheral blood and tumor-infiltrating T lymphocytes from women with squamous intraepithelial lesions (SIL) or cervical cancer (CC).

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关键词

Peripheral and infiltrating T cells,cervical cancer,CD3ζ expression,IL-10,TGF-β1.

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