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Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

Tomohiro Ohashi,Yuya Oguro,Toshio Tanaka,Zenyu Shiokawa,Yuta Tanaka,Sachio Shibata,Yoshihiko Sato,Hiroko Yamakawa,Harumi Hattori,Yukiko Yamamoto,Shigeru Kondo,Maki Miyamoto,Mitsuhiro Nishihara,Yoshimasa Ishimura,Hideaki Tojo,Atsuo Baba,Satoshi Sasaki

Bioorganic & Medicinal Chemistry（2012）

Cited 66|Views16
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Key words
Hedgehog,Hh signaling inhibitor,Pyrrolo[3,2-c]pyridine-4-one,TAK-441
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