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Hyperalgesia by low doses of the local anesthetic lidocaine involves cannabinoid signaling: an fMRI study in mice.

Simone C Bosshard,Joanes Grandjean,Aileen Schroeter,Christof Baltes,Hanns U Zeilhofer,Markus Rudin

PAIN（2012）

Cited 13|Views1
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Abstract
Functional magnetic resonance imaging in wild-type and CB1 receptor knockout mice revealed that lidocaine at low doses induces hyperalgesia, predominantly mediated by CB1 receptors located on nociceptors.
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Key words
Functional magnetic resonance imaging,Mice,Lidocaine,Hyperalgesia,Cannabinoid receptor CB1
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