Discovery of A Series of 2-(1H-pyrazol-1-yl)pyridines As Alk5 Inhibitors with Potential Utility in the Prevention of Dermal Scarring
Mark L. Boys,Feng Bian,James B. Kramer,Christopher L. Chio,Xiao-Dan Ren,Huifen Chen,Stephen D. Barrett,Karen E. Sexton,Donna M. Iula,Gary F. Filzen,Maria N. Nguyen,Paul Angell,Victoria L. Downs,Zhi Wang,Neil Raheja,Edmund L. Ellsworth,Stephen Fakhoury,Larry D. Bratton, Paul R. Keller,Richard Gowan,Elena M. Drummond,Samarendra N. Maiti,Mostofa A. Hena, Leroy Lu,Patrick McConnell,John D. Knafels,Venkataraman Thanabal,Fang Sun, Diane Alessi, Ann McCarthy,Erli Zhang,Barry C. Finzel, Sneha Patel,Susan M. Ciotti,Rone Eisma, N. A. Payne,Richard B. Gilbertsen,Catherine R. Kostlan,David J. Pocalyko,Deepak S. Lala Bioorganic & medicinal chemistry letters（2012）
关键词
Activin receptor-like Kinase 5,Transforming growth factor beta,Topical,Dermal scarring,Wound repair
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