Clinical Efficacy Of Left Ventricular Pacing Vector Programmability In Cardiac Resynchronization Therapy Defibrillator Patients For Management Of Phrenic Nerve Stimulation And/Or Elevated Left Ventricular Pacing Thresholds: Insights From The Efface Phrenic Stim Study

Elevated left ventricular (LV) pacing thresholds or phrenic nerve stimulation (PNS) might be possible reasons for absence of continuous and effective biventricular stimulation. This study investigated the benefit and clinical efficacy of the ability to choose one out of three different LV pacing vectors for the management of suboptimal LV pacing thresholds and PNS.This prospective, observational multicentre study enrolled 132 patients (Pts) implanted with a cardiac resynchronization therapy defibrillator, that offers three LV pacing vectors: (i) Bipolar; (ii) LVtipRVcoil; (iii) LVringRVcoil (RV right ventricular). Left ventricular pacing thresholds and PNS thresholds were obtained in sitting and left lateral body position for all programmable LV pacing vectors at hospital discharge and follow up (FU). In 97, a bipolar transvenous LV lead was successfully implanted. In 87 of Pts at least one acceptable pacing vector could be identified that provides good pacing threshold (2.5 V at 5 ms) and acceptable margin to PNS (epsilon 2:1). This is an increase of 18 compared with conventional bipolar systems (74) with two LV vectors and of 25 compared with unipolar systems (70). The LVtipRVcoil vector provided the best LV pacing thresholds, but the highest rate of PNS.The programmability of LV pacing vectors is a powerful feature to avoid PNS and obtain acceptable LV pacing thresholds. In order to retain reprogramming options for LV vectors during FU, LV pacing leads with at least two electrodes should be chosen whenever possible.