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Contribution of Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 to Hepatic Uptake of Nateglinide, and the Prediction of Drug–drug Interactions Via These Transporters

Toshiyuki Takanohashi, Satoru Kubo,Harumi Arisaka,Kenji Shinkai,Kazuyuki Ubukata

Journal of pharmacy and pharmacology（2011）

Cited 15|Views5
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Abstract
Objectives  We have investigated the contributions of organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 to the hepatic uptake of nateglinide, and the possibility of drug–drug interactions via these transporters.
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Key words
drug-drug interaction,nateglinide,OATP1B3,organic anion transporting polypeptide (OATP) 1B1
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