Candidate Inflammatory Biomarkers Display Unique Relationships with Alpha-Synuclein and Correlate with Measures of Disease Severity in Subjects with Parkinson’s Disease

Lori N. Eidson,George T. Kannarkat,Christopher J. Barnum,Jianjun Chang,Jaegwon Chung,Chelsea Caspell-Garcia,Peggy Taylor,Brit Mollenhauer,Michael G. Schlossmacher,Larry Ereshefsky,Mark Yen,Catherine Kopil,Mark Frasier,Kenneth Marek,Vicki S. Hertzberg,Malú G. Tansey

Journal of neuroinflammation（2017）SCI 1区

Cited 59|Views49

Abstract

Efforts to identify fluid biomarkers of Parkinson’s disease (PD) have intensified in the last decade. As the role of inflammation in PD pathophysiology becomes increasingly recognized, investigators aim to define inflammatory signatures to help elucidate underlying mechanisms of disease pathogenesis and aid in identification of patients with inflammatory endophenotypes that could benefit from immunomodulatory interventions. However, discordant results in the literature and a lack of information regarding the stability of inflammatory factors over a 24-h period have hampered progress.

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Key words

Parkinson’s disease,Inflammation,Protein biomarkers,Daily rhythm,CSF,Serum

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