Polyclonal Expansion of Cd3(+)/Cd4(+)/Cd56(+) Large Granular Lymphocytes and Autoimmunity Associated with Dysregulation of Fas/Fasl Apoptotic Pathway
British journal of haematology(2001)
摘要
Evidence is accumulating regarding CD95/CD95 ligand (Fas/FasL) pathway dysregulation in clonal diseases of the lymphohaemopoietic lineages. According to these observations, it has been proposed that this defect may represent one of the mechanisms of tumour progression. In large granular lymphocyte (LGL) leukaemia, dysregulated apoptosis may represent a key event in the development of malignancy and autoimmunity. This case report describes dysregulation of the Fas/FasL pathway in a chronic polyclonal expansion of CD3(+) LGLs associated with numerous serological immune abnormalities.
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关键词
apoptosis,autoimmunity,large granular lymphocytes,CD95,polyclonal proliferation
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