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Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.

Vito Guagnano,Pascal Furet,Carsten Spanka, Vincent Bordas,Mickaël Le Douget,Christelle Stamm,Josef Brueggen,Michael R Jensen,Christian Schnell,Herbert Schmid,Markus Wartmann,Joerg Berghausen,Peter Drueckes,Alfred Zimmerlin,Dirksen Bussiere,Jeremy Murray,Diana Graus Porta

JOURNAL OF MEDICINAL CHEMISTRY（2011）

Cited 392|Views38
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Key words
fibroblast growth factor,kinase,selective inhibitor,dimethoxy-phenyl,ethyl-piperazin,phenylamino]-pyrimidin,methyl-urea,nvp-bgj
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