Human Cytomegalovirus IE1 Promoter/enhancer Drives Variable Gene Expression in All Fiber Types in Transgenic Mouse Skeletal Muscle.
BMC genomic data(2000)
摘要
Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the transcriptionally specialized fiber types of which muscle is composed. "Universal" viral promoters/enhancers, e.g., cytomegalovirus IE1 (CMV IE1), are of interest as reagents that may drive broad expression. However, a previous study noted a marked heterogeneity of CMV IE1-driven transgene expression among muscle fibers, raising the possibility of fiber-type-restricted expression. The purpose of the present study was to characterize CMV IE1-driven expression in terms of fiber type.
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关键词
Fiber Type,Soleus Muscle,Muscle Region,Medial Gastrocnemius,Slow Fiber
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