Immune Reconstitution Syndromes in Human Immunodeficiency Virus Infection Following Effective Antiretroviral Therapy
Immunobiology(2000)
摘要
Effective antiretroviral therapy leads to rapid decrease in plasma HIV-1 RNA, frequently followed by an increase in CD4 T-helper cell counts. The improvement of immune function during highly active antiretroviral therapy has important impact on natural history of AIDS-related opportunistic disorders. Here we describe cases of unusual clinical inflammatory syndromes in CMV retinitis, hepatitis C, and atypical mycobacteriosis in HIV-1 infected patients associated with the initiation of antiretroviral therapy. Pathogenetic implications and therapeutic management of these new immunopathologic syndromes are discussed.
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关键词
HIV,AIDS,CMV,MAC,HAART,HCV
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