Disrupting the Reader of Histone Language.
Angewandte Chemie (International ed in English)(2011)
摘要
New targets, new drugs: In the context of regulating gene expression, small molecules have been found that specifically disrupt the interaction between the “reader” (e.g. a protein with a bromodomain) and chromatin. These results provide compelling proof-of-concept that disrupting histone readers is a viable strategy for the development of epigenetic drugs. (The picture shows the complex formed by (+)-JQ1 and the bromodomain hBRD2.)
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关键词
Epigenetic Readers
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