The relationship between serum trace elements, vitamin B12, folic acid and clinical parameters in patients with myofascial pain syndrome.

Background: Myofascial pain syndrome (MPS) is characterized by myofascial trigger points in a palpable taut band of skeletal muscle. Objective: We aimed to investigate serum trace elements, vitamin B 12, folic acid levels and their correlations with clinical findings and functional status in patients with MPS. Methods: Thirty eight patients with at least one trigger point located on shoulder muscles, and at least 6 months duration, were included in this study. The demographic data, disease duration of patients were noted. Serum copper, zinc, magnesium and iron levels, vitamin B 12 and folic acid levels were measured. Visual analogue scale (VAS) was implemented to estimate daily severity of pain. Pain pressure threshold of subjects and control groups were assessed by using Fischer's tissue compliancemeter. The Turkish version of the Beck Depression Inventory (BDI) was administered for the presence of any depressive disorder. Results: The mean age of patients in MPS group and control group were 33.1 and 37.8 years respectively. Serum levels of zinc (p < 0.006) were significantly decreased in patients with MPS. VAS, total myalgic and BDI scores of patients were significantly higher than the control group (Respectively p < 0.000, p < 0.012, p < 0.000). Association between TMS and magnesium, vitamin B 12 levels was found statistically significant. BDI score correlated significantly with the serum zinc level (r:-0.548, p < 0.001) and VAS in patients with MPS (r: 0.641, p < 0.000). Conclusion: According to the results of this study, it was asserted that trace elements, vitamins may play an important role in the pathophysiology of MPS and psychological factors may also have additional effect.