The disposition of debrisoquine in hypertensive patients.

British Journal of Clinical PharmacologyVolume 5, Issue 1 p. 27-34 Free Access The disposition of debrisoquine in hypertensive patients. JH Silas, JH SilasSearch for more papers by this authorMS Lennard, MS LennardSearch for more papers by this authorGT Tucker, GT TuckerSearch for more papers by this authorAJ Smith, AJ SmithSearch for more papers by this authorSL Malcolm, SL MalcolmSearch for more papers by this authorTR Marten, TR MartenSearch for more papers by this author JH Silas, JH SilasSearch for more papers by this authorMS Lennard, MS LennardSearch for more papers by this authorGT Tucker, GT TuckerSearch for more papers by this authorAJ Smith, AJ SmithSearch for more papers by this authorSL Malcolm, SL MalcolmSearch for more papers by this authorTR Marten, TR MartenSearch for more papers by this author First published: January 1978 https://doi.org/10.1111/j.1365-2125.1978.tb01594.xCitations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References ALLEN. J.G., EAST, P.B., FRANCIS, R.J. & HAIGH, J.L. (1975). Metabolism of debrisoquine: identification of some urinary metabolites in rat and man. Drug Metab. Dispos., 3, 332–337. CASPubMedWeb of Science®Google Scholar ANGELO, M., DRING, L.G., LANCASTER, R. & SMITH, R.L. (1976). The metabolism of debrisoquine in rat and man Biochem. Soc. Trans., 704–706. Google Scholar CHREMOS, A.N., SHEN, D., GIBALDI, M., PROCTOR, J.D. & NEWMAN, J.H. (1976). Time dependent change in renal clearance of bethanidine in humans. J. pharm. Sci., 65, 140–142. 10.1002/jps.2600650136 CASPubMedWeb of Science®Google Scholar LENNARD, M.S., SILAS, J.H., SMITH, A.J. & TUCKER, G.T. (1977a). Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame ionization and nitrogen-selective detection. J. Chromatogr., 133, 161–166. 10.1016/S0021-9673(00)89216-X CASPubMedWeb of Science®Google Scholar LENNARD, M.S., SILAS, J.H., SMITH, A.J. & TUCKER, G.T. (1977b). Concentration of debrisoquine by human platelets in vivo: Relationship to hypotensive effect. Br. J. clin. Pharmac., 4, 000–000. 10.1111/j.1365-2125.1977.tb00807.x CASGoogle Scholar MALCOLM, S.L. & MARTEN, T.R. (1976). Determination of debrisoquine and its 4-hydroxy metabolite in plasma by gas chromatography/mass spectroscopy. Analyt. Chem., 48, 807–809. 10.1021/ac60370a045 CASPubMedWeb of Science®Google Scholar PATERSON, J.W., CONOLLY, M.E., DOLLERY, C.T., HAYES. A.H. & COOPER, R.G. (1970). The pharmacodynamics and metabolism of propranolol in man. Pharmacologica Clin., 2, 127–133. 10.1007/BF00420338 CASGoogle Scholar SHEN, D., GIBALDI, M., THORNE, M., AILWARD, G., CUNNINGHAM, R., ISRAILI, Z., DAYTON, P. & McNAY, J. (1975). Pharmacokinetics of bethanidine in hypertensive patients. Clin. Pharmac. Ther., 17, 363–373. 10.1002/cpt1975173363 CASPubMedWeb of Science®Google Scholar SILAS, J.H., LENNARD, M.S., TUCKER, G.T., SMITH, A.J., MALCOLM, S.L. & MARTEN, T.R. (1977). Why hypertensive patients vary in their response to oral debrisoquine. Br. med. J., 1, 422–425. 10.1136/bmj.1.6058.422 CASPubMedWeb of Science®Google Scholar SOLOMON, H.M., ASHLEY, C., SPIRIT, N. & ABRAMS, W.B. (1969). The influence of debrisoquine on the accumulation and metabolism of biogenic amines by the human platelet, in vivo and in vitro Clin. Pharmac. Ther., 10, 229–238. 10.1002/cpt1969102229 CASPubMedWeb of Science®Google Scholar TALBOT, S., O'MALLEY, B.C., BING, R.F. (1975). Debrisoquine, guanethidine and bethanidine in hypertension. Br. med. J., 2, 278. 10.1136/bmj.2.5965.278-b CASPubMedWeb of Science®Google Scholar TURNBULL, L.B., TING, L., NEWMAN, J., CHREMOS, A.N. & BRUCE, R.B. (1976). Disposition of bethanidine, N-benzyl-N′, N″-dimethylguanidine in the rat, dog and man. Drug Metab. Dispos., 4, 269–275. CASPubMedWeb of Science®Google Scholar Citing Literature Volume5, Issue1January 1978Pages 27-34 ReferencesRelatedInformation