Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.

Izzat T Raheem, Michael J Breslin,Joseph Bruno,Tamara D Cabalu,Andrew Cooke,Christopher D Cox,Donghui Cui,Susan Garson,Anthony L Gotter,Steven V Fox,C Meacham Harrell,Scott D Kuduk,Wei Lemaire,Thomayant Prueksaritanont,John J Renger,Craig Stump,Pamela L Tannenbaum,Peter D Williams,Christopher J Winrow,Paul J Coleman

Bioorganic & Medicinal Chemistry Letters（2015）

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关键词

Selective orexin receptor antagonist (SORA),Dual orexin receptor antagonist (DORA),Active wake,Delta sleep,REM sleep,Filorexant

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